Labor advocate and Palantine town supervisor Sara Niccoli on Monday announced her exploratory bid for the state Senate seat held by Republican Sen. George Amedore.

Niccoli in a fundraising appeal said she would be taking on Albany’s “pay-to-play culture” the blocks reform.

“Sending politicians with deep pocketed connections to Albany isn’t working for the people of New York State and the 46th Senate District,” Niccoli wrote in the fundraising appeal. “Those aren’t my connections. My connections are to the farmers, small business owners, students, teachers, builders, nurses, caregivers, technicians, retail workers, and families of my community. I believe that, together, we have the power and resources we need to change Albany. You are the backbone of this fight — and my successful candidacy depends on you.”

Amedore, Niccoli wrote in the email, “exemplifies everything that’s wrong with Albany.”

The email was first reported this morning by The Times Union.

The 46th Senate district was first carved out of the Mohawk and Hudson valleys by Senate Republicans during the 2012 round of redistricting. Seemingly drawn for Amedore, then a state Assembly, the seat was narrowly won that year by Democrat Cecilia Tkaczyk.

Amedore in 2014 in a comeback bid defeated Tkaczyk for the seat, one of several Republican gains that year in the state Senate.

The district could once again be a battleground seat: In the last election cycle, millions of dollars from outside groups and independent expenditure committees poured into the district, with mailboxes stuffed with flyers and the airwaves carrying ads from both candidates and their supporters.

Senate Republicans sought to link Tkaczyk, along with her fellow Senate Democratic incumbents, to New York City Mayor Bill de Blasio, who was actively seeking a Democratic takeover of the chamber that year.

Niccoli already is making an issue out of Amedore’s support.

“His campaigns are funded by the same wealthy downstate developers at the heart of recent corruption scandals,” Niccoli wrote in the email. “He broke his promise to stop failed Common Core policies by voting to fund and extend them while diverting millions of education dollars to New York City charter schools. As low-wage workers are forced to rely on taxpayer-funded public assistance, he stands in the way of a minimum wage increase.”