Gov. Andrew Cuomo holds wide leads over his potential general election and party primary challengers, a Siena College poll released Monday found.

The poll found Cuomo would handily defeat actress and public education advocate Cynthia Nixon in a Democratic primary, 66 percent to 19 percent.

At the same time, Cuomo holds identical leads over potential Republican nominees, Dutchess County Executive Marc Molinaro and state Sen. John DeFrancisco.

Cuomo leads Molinaro 57 percent to 29 and DeFrancisco 57 percent to 28 percent, the poll found. Both Molinaro and DeFrancisco remain largely unknown to voters.

Nixon, meanwhile, holds a 20 percent to 19 percent favorability rating, with 60 percent of voters not having an opinion or knowing enough about her. Nixon is yet to declare whether she will run for governor, while Molinaro is due to formally enter the race on April 2 after locking down key Republican county chairs.

It was similarly good news for another statewide Democrat up for re-election this year: U.S. Sen. Kirsten Gillibrand holds a wide lead over her little-known GOP challenger Chele Farely, 60 percent to 24 percent.

Meanwhile, Cuomo’s favorability rating fell to 52 percent to 40 percent, though that remains little changed from last month — suggesting the trial of the governor’s former top aide Joe Percoco did little to sway voters’ opinions and take its toll on Cuomo. Percoco was found guilty of three counts of federal corruption.

More importantly for a potential Democratic primary, 69 percent of liberals and 68 percent of Democrats also hold a favorable view of him.

The poll found 48 percent of voters are prepared to re-elect Cuomo to a third term while 46 percent surveyed prefer someone else. A plurality of voters, 46 percent, would describe Cuomo as a “liberal.”

While Percoco’s trial played out in New York City, Cuomo has spent the last month emphasizing key issues for the base of the party, ranging from LGBTQ rights to gun control and rolling out a series of high-profile endorsements in the process.

Cuomo’s signature gun control law, the SAFE Act, remains popular with voters: 61 percent to 28 percent continue to back the law that was first approved five years ago in the wake of a Connecticut school shooting.

A wide majority 69 percent to 28 percent, oppose arming teachers.

Lawmakers have since February debated gun control legislation that include measures geared toward strengthening background checks, banning bump stocks and making it harder for the dangerously mentally ill to purchase a firearm.

Senate Republicans want to bolster school security measures, adding money for new security equipment and bringing in school resource officers.

Cuomo on Sunday endorsed a provision that would extend background checks for gun purchases up to 10 days. The poll released Monday found the expanded background check period is supported by 90 percent of voters surveyed.

The poll of 772 registered voters was conducted from March 11 to March 16. It has a margin of error of 4 percentage points.